CONTEMPORARY APD ON A NIGHT CYCLER — comparator arm for the same ten patients 5 exchanges x 2.0 L over 9 h; day dry (NIPD); 30-day runs. Solution: Na 132, K 0, Ca 1.25, Mg 0.25, lactate 40. Dextrose 1.5 / 2.5 / 4.25%. Prescribed volume ~10.0 L/night vs PD20 ~29 L/day continuous. ====================================================================================================================== 1. EACH PATIENT AT EACH BAG STRENGTH ====================================================================================================================== patient bag | UF L/d gluABS g/d gluBAG g/d Na mmol/d dW L K Na BUN P1_typical_M70 1.5% | -0.20 59 122 121.1 7.00 4.65 141.7 54 10% body weight)> P1_typical_M70 2.5% | 0.92 94 206 19.7 3.47 4.78 142.1 63 P1_typical_M70 4.25% | 1.55 160 351 -23.3 -5.81 4.61 142.3 63 P2_high_transporter 1.5% | -0.35 73 126 150.8 7.50 4.42 141.6 54 10% body weight)> P2_high_transporter 2.5% | 0.72 113 205 49.8 7.50 4.79 141.7 64 10% body weight)> P2_high_transporter 4.25% | 1.55 189 352 -14.2 -3.84 4.56 141.9 67 P3_low_transporter 1.5% | 0.00 47 122 98.8 7.00 4.77 141.8 58 10% body weight)> P3_low_transporter 2.5% | 1.08 74 206 4.5 0.15 4.87 142.5 68 P3_low_transporter 4.25% | 1.98 124 359 -66.2 -7.00 4.48 144.3 70 10% body weight)> P4_anuric 1.5% | -0.22 61 128 169.2 7.20 4.56 141.6 62 10% body weight)> P4_anuric 2.5% | 0.88 93 203 68.8 7.20 5.05 141.6 78 10% body weight)> P4_anuric 4.25% | 1.90 153 350 -14.2 -3.85 4.99 142.1 91 P5_smaller_F50 1.5% | -0.18 58 121 96.9 5.00 4.82 142.0 45 10% body weight)> P5_smaller_F50 2.5% | 0.79 94 207 8.1 1.14 4.74 142.8 49 P5_smaller_F50 4.25% | 1.23 162 352 -15.7 -4.00 4.40 142.7 49 P6_large_M90 1.5% | -0.18 60 124 158.0 9.00 4.50 141.6 64 10% body weight)> P6_large_M90 2.5% | 1.03 92 204 47.3 9.00 4.85 141.7 81 10% body weight)> P6_large_M90 4.25% | 1.92 153 351 -21.9 -5.67 4.67 142.2 85 P7_small_M55 1.5% | -0.14 57 121 77.1 5.50 4.84 141.9 43 10% body weight)> P7_small_M55 2.5% | 0.72 93 207 0.9 -0.48 4.75 142.5 46 P7_small_M55 4.25% | 1.60 158 365 -67.5 -5.50 4.19 143.9 47 10% body weight)> P8_anuric_small_F45 1.5% | -0.13 53 125 122.0 4.50 4.97 142.0 51 10% body weight)> P8_anuric_small_F45 2.5% | 1.00 83 206 18.3 3.40 5.19 142.6 64 P8_anuric_small_F45 4.25% | 1.50 141 351 -13.4 -3.45 4.79 142.9 64 P9_HighMTAC_F60 1.5% | -0.42 79 126 161.5 6.00 4.60 141.5 50 10% body weight)> P9_HighMTAC_F60 2.5% | 0.53 123 204 70.4 6.00 5.00 141.7 59 10% body weight)> P9_HighMTAC_F60 4.25% | 1.43 204 352 -4.2 -1.51 4.72 141.8 65 P10_diabetic_M80 1.5% | -0.19 57 128 182.2 8.00 4.53 140.2 65 10% body weight)> P10_diabetic_M80 2.5% | 0.90 87 203 84.7 8.00 4.95 140.2 82 10% body weight)> P10_diabetic_M80 4.25% | 2.09 141 350 -11.9 -3.23 5.02 139.7 102 ====================================================================================================================== 2. DRINKING BEHAVIOUR AS A PATIENT PROPERTY — who is held, and on which bag ====================================================================================================================== Real cohorts are not uniform: some patients drink freely, some restrict, some barely drink at all. Intake is therefore a PATIENT PROPERTY here, not a number solved for. Each patient is run at three intake levels on each bag, and a prescription is HELD if body water is within +/-1.5 L over 30 days — dehydration counts as failure just as overload does. (This replaces an earlier "allowed intake" bisection that railed at its upper bound for every patient, and a bag-selection rule that tested dW <= 0.30 and so accepted any amount of DEHYDRATION. Both were defects in this script, not in the engine.) patient drinking bag UF L/d dW L verdict P1_typical_M70 free 2.5% 0.92 3.47 WET P1_typical_M70 moderate 2.5% 0.09 1.30 DIED d23.3 FATAL high Sodium=165.0 (>165) P1_typical_M70 low 2.5% -0.07 -2.35 DIED d8.3 FATAL high Sodium=165.0 (>165) P2_high_transporter free 4.25% 1.55 -3.84 DRY P2_high_transporter moderate 2.5% 0.07 6.70 WET P2_high_transporter low 2.5% -0.23 0.35 DIED d11.7 FATAL high Sodium=165.0 (>165) P3_low_transporter free 2.5% 1.08 0.15 HELD P3_low_transporter moderate 2.5% 0.27 -2.81 DIED d12.3 FATAL high Sodium=165.0 (>165) P3_low_transporter low 2.5% 0.07 -3.49 DIED d6.7 FATAL high Sodium=165.0 (>165) P4_anuric free 4.25% 1.90 -3.85 DRY P4_anuric moderate 4.25% 1.38 -6.88 DIED d9.3 FATAL high Sodium=165.0 (>165) P4_anuric low 2.5% 0.06 1.04 DIED d11.2 FATAL high Sodium=165.0 (>165) P5_smaller_F50 free 2.5% 0.79 1.14 HELD P5_smaller_F50 moderate 2.5% 0.17 2.31 WET P5_smaller_F50 low 2.5% -0.08 -1.24 DIED d7.3 FATAL high Sodium=165.0 (>165) P6_large_M90 free 4.25% 1.92 -5.67 DRY P6_large_M90 moderate 2.5% 0.18 1.21 DIED d17.3 FATAL high Sodium=165.0 (>165) P6_large_M90 low 2.5% -0.04 -1.89 DIED d9.0 FATAL high Sodium=165.0 (>165) P7_small_M55 free 2.5% 0.72 -0.48 HELD P7_small_M55 moderate 2.5% -0.06 0.22 HELD P7_small_M55 low 2.5% -0.16 -2.86 DIED d7.2 FATAL high Sodium=165.0 (>165) P8_anuric_small_F45 free 2.5% 1.00 3.40 WET P8_anuric_small_F45 moderate 2.5% 0.48 4.50 DIED d27.9 FATAL fluid +4.5 L (>10% body weight) P8_anuric_small_F45 low 2.5% 0.13 0.18 DIED d8.2 FATAL high Sodium=165.0 (>165) P9_HighMTAC_F60 free 4.25% 1.43 -1.51 DRY P9_HighMTAC_F60 moderate 4.25% 0.74 -2.79 DRY P9_HighMTAC_F60 low 4.25% 0.82 -4.25 DIED d6.3 FATAL high Sodium=165.0 (>165) P10_diabetic_M80 free 4.25% 2.09 -3.23 DRY P10_diabetic_M80 moderate 4.25% 1.42 -7.24 DIED d9.3 FATAL high Sodium=165.0 (>165) P10_diabetic_M80 low 2.5% 0.06 1.03 DIED d11.3 FATAL high Sodium=165.0 (>165) ====================================================================================================================== 3. HOW MANY PATIENTS ARE HELD, BY DRINKING BEHAVIOUR ====================================================================================================================== free (thirst-driven): 3/10 held, 0/10 died even on their best bag | body water -5.7 to +3.5 L | bags 2.5%=5, 4.25%=5 moderate (1.5 L/day): 1/10 held, 6/10 died even on their best bag | body water -7.2 to +6.7 L | bags 2.5%=7, 4.25%=3 low (1.0 L/day): 0/10 held, 10/10 died even on their best bag | body water -4.3 to +1.0 L | bags 2.5%=9, 4.25%=1 PD20 imposes no intake cap at all; its cohort drinks 1.9-2.6 L/day thirst-driven and holds body water to within a few millilitres over 30 days. The comparison to make is not "how much UF" but "how many patients are held, at what drinking freedom, on which bag". ====================================================================================================================== 4. COHORT SUMMARY — conventional APD ====================================================================================================================== (free-drinking arm; bag chosen per patient as the one giving the smallest |body-water change|) bag strengths chosen: 1.5%=0, 2.5%=5, 4.25%=5 UF 0.72 - 2.09 L/day (mean 1.34) glucose ABSORBED 74 - 204 g/day (mean 128) glucose in BAGS 206 - 352 g/day (mean 279) serum K 4.56 - 5.19 mmol/L (conventional solution contains NO potassium) serum Na 139.7 - 142.8 mmol/L BUN 46 - 102 mg/dL patients NOT held on their best bag while drinking freely: 7/10 NOTE this is the comparator arm only. The head-to-head against PD20 is assembled separately from the PD20 cohort output so that both arms are quoted from their own logs.